منابع مشابه
Total synthesis of cyanolide A.
The total synthesis of cyanolide A has been achieved in 14 steps from commercially available (S)-2-ethyloxirane, exploiting the palladium-catalyzed intramolecular alkoxycarbonylation as the key step to construct the tetrasubstituted cis-tetrahydropyran ring with high stereoselectivity.
متن کاملTotal Synthesis of Putative 11-epi-Lyngbouilloside Aglycon
We report here the total synthesis of 11-epi-lyngbouilloside aglycon. Our strategy features a Boeckman-type esterification followed by a RCM to form the 14-membered ring macrolactone and a late-stage side chain introduction via a Wittig olefination. Overall, the final product was obtained in 20 steps and 2% overall yield starting from commercially available 3-methyl-but-3-enol. Most importantly...
متن کاملTotal synthesis of cyanolide A and confirmation of its absolute configuration.
The tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent effect and the 2-methyl-6-nitrobenzoic anhydride (MNBA)-mediated dimerization were explored for the efficient and facile synthesis of cyanolide A.
متن کاملEnantioselective Synthesis of the Elaiophylin Aglycon.
Elaiophylin (1) was isolated in 1959 by Arcamone and co-workers from cultures of Streptomyces melanosporus.1 Subsequently, this natural product has also been obtained from other strains of Streptomyces.2 Structure elucidation of 1, including assignment of absolute stereochemistry, was based on chemical degradation,3 NMR studies,4 and ultimately X-ray crystallographic analysis.5 Isolation and ch...
متن کاملTotal synthesis of the protected aglycon of fidaxomicin (tiacumicin B, lipiarmycin A3).
Fidaxomicin, also known as tiacumicin B or lipiarmycin A3, is a novel macrocyclic antibiotic that is used in hospitals for the treatment of Clostridium difficile infections. This natural product has also been shown to have excellent bactericidal activity against multidrug-resistant Mycobacterium tuberculosis. In spite of its attractive biological activity, no total synthesis has been reported t...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2011
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja204228q